Blood Clotting Disorders - PAI-1
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9/20/2010 8:46 PM
WannaBe - Thanks, I replied over there. I appreciate it!

9/20/2010 8:08 PM
Hey GirlAtHeart....I posted you on the "General Discussion" page!

9/20/2010 8:08 PM
Hey GirlAtHeart....I posted you on the "General Discussion" page!

9/19/2010 10:37 PM
Hi All,

I haven't been on this site in about a year. Some of you "know" me and my history: I've done three IVF cycles and have gotten pregnant twice. Both times ended in miscarriage.

I begged to get tested after the first miscarriage, but my doctor wouldn't do them. So after the second one, they finally did the testing.

The tests revealed that I am positive for a gene mutation called Plasminogen Activator Inhibitor - (PAI-1 for short). PAI-1 is some type of blood clotting issue. My clinic asked me to start taking a baby aspirin daily. I also have an appointment to see a specialist (hematologist) at the end of October.

According to my IVF nurse, they have me on the aspirin to thin my blood, and then mentioned that I may have to take Lovenox just before I start my cycle - I think that's what she said. (I plan on doing a frozen cycle in mid to late November.) Also, they will not put me on birth control this time because of the risks of clots. I will just go straight to Lupron.

Does anyone have this gene mutation? If yes, what protocol did you do? Did you see the hematologist? Also, do you have to take extra folic acid and B-12 or B-6.

My internet research (Google) is confusing. I do not have MTHFR, but I think I keep reading information that indicates PAI-1 positive women need to also take extra folic acid, B vitamins, etc. I currently take a pre-natal with 1 mg folic acid and an additional 800 mcg folic acid tablet.

Thank you to anyone who can give me information. I don't want to bug my clinic. I did speak with the nurse, but it was confusing. I'm currently on board to call her back mid-October with my period.

Things to Be Happy About: I do feel like I am steps closer to a successful outcome in that I had surgery this summer and removed two fibroids and a polyp. This "straightened" my uterus, which was being pushed to the side. I'm also losing the 10 lbs. I gained last cycle.

I can be reached here or on "Daily Strength dot org" under GirlAtHeart.

(I will also post this under a few other categories here, so pardon the redundancy.)
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